Chemical Proteomics Identifies Unanticipated Targets of Clinical Kinase Inhibitors
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چکیده
منابع مشابه
Quantitative Chemical Proteomics Identifies Novel Targets of the Anti-cancer Multi-kinase Inhibitor E-3810*
Novel drugs are designed against specific molecular targets, but almost unavoidably they bind non-targets, which can cause additional biological effects that may result in increased activity or, more frequently, undesired toxicity. Chemical proteomics is an ideal approach for the systematic identification of drug targets and off-targets, allowing unbiased screening of candidate interactors in t...
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ژورنال
عنوان ژورنال: ACS Chemical Biology
سال: 2007
ISSN: 1554-8929,1554-8937
DOI: 10.1021/cb700203j